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A549 Downregulated Genes (Dex)

Source: R/data.R
a549_dex_downreg.Rd

Example gene set of downregulated (repressed) genes in A549 cells after dexamethasone treatment. To keep the dataset small and suitable for examples and tests, only the first 15 downregulated gene symbols are included here.

Usage

a549_dex_downreg

Format

A character vector of length 15, containing HGNC gene symbols.

Source

Supplementary Table S3 from Tav et al. (2023).

Details

The full list of differentially expressed genes (activated and repressed) is provided as Supplementary Table S3 in Tav et al. (2023). The raw Excel file can be downloaded directly from Frontiers in Genetics: https://www.frontiersin.org/api/v4/articles/1237092/file/Table_3.XLSX/1237092_supplementary-materials_tables_3_xlsx/1.

In this package, we subset the data to only the first 15 repressed genes, which are stored in the object a549_dex_downreg.

References

Tav C, Fournier É, Fournier M, Khadangi F, Baguette A, Côté MC, Silveira MAD, Bérubé-Simard F-A, Bourque G, Droit A, Bilodeau S (2023). "Glucocorticoid stimulation induces regionalized gene responses within topologically associating domains." Frontiers in Genetics. doi:10.3389/fgene.2023.1237092

Examples

# Load dataset
data(a549_dex_downreg)
a549_dex_downreg
#>  [1] "MIR23AHG" "IER2"     "BHLHE40"  "IER3"     "PLK2"     "EDN1"    
#>  [7] "NUAK2"    "HES1"     "GEM"      "IER5"     "MEGF6"    "MTCO2P12"
#> [13] "DHRS3"    "PTAFR"    "EPHA2"